Yes you certainly can. But, please understand that while this will work, there will be times where due to a internet issue or perhaps a SmartThings issue, that the siren will not fire immediately on door opening. In short, due to the cloud nature of SmartThings it might not be wise to trust your security at this point to it. I love ST, but there are issues with reliability. Now, if this is meant to do a general alarm, where you do not mind if it fires a minute later (Actually might do better if you are looking to scare people off, as the timing would not be on door open but rather just as they enter).
Re-reading your message, I see that you want the siren to go off after a delay. So yes this would work for you just fine, and you have stated all that you need above. Door Sensor. Siren, and Hub. I would recommend that you use the ST Open/Close sensor since it is the same price and offers additional features. You may also consider the ST Multisensor that also adds vibration detection.