If I understand you correctly YES. I have one of mine in bedroom that actually has no lights connected directly to its LOAD terminals other than a outlet. I use a smartapp that monitors the button actions of the switch in that bedroom to control three separate smart bulbs individually based on how I am pressing, single, double, etc.
Yes. You can get the details on setting it up at a thread here started up by @bamarayne for getting assistance on CoRE applications that might help you best. CoRE - Get peer assistance here with setting up Pistons