Yes, my Zoned Heating/Cooling solutions work well with the Nest. I have some Nest contributors
and they are quite happy with it (amongst others @DreamPunk who has been using the smartapp for more than 1 year).
You’d need this smartapp:
Or, there is also a scaled down version of it (called ScheduleRoomTempControl), designed just for the vent settings.
See this thread for more details on my Zoned Heating/Cooling Solutions:
P.S. My Zoned Solutions are now officially approved by Keen Home…