How to wire switch with no load

I think what I’m trying to do is similar… I did it in our old house with UPB. But the new house I went with ST. I have two lights outside (L1 & L2), I have two different light switches on different walls (S1 & S2). I’d like to use S1 to turn L1 & L2 on/off…AND I’d like to repurpose S2 to turn on / off DIFFERENT lights, L3, and no longer control L2. Possible? I know I was able to do that with Simply Automated UPB… I currently have the Samsung SmartThings hub v3 and Leviton Zwave dimmers. Can I do this with what I have or do I need a different switch?
Thank You!