Yes you can have SmartThings operate the 3-way control in a similar fashion. Do you want dimming or just on-off 3-way operation? Dimming will bring in a more complex programming solution.
As far as I know the HomeSeer switches are not directly designed to be used in 3-way or 4-way standalone operation so if you use a hub (HomeSeer or SmartThings) you can make them operate indirectly in 3-way as long as the home automation hub is operational.
A disadvantage is the latency of the “secondary” switches when you want the 3-way operation versus standalone control. Personal preference will determine if latency is acceptable or not but it is not a bother for most once they get used to how it operates versus the instantaneous operation of the original hardwired switches
An advantage is you don’t have to use HomeSeer switches in the secondary switch locations, any hub compatible switch or button device could be used to signal you want the lights on from the secondary location and triggering the primary location of the HomeSeer HD100+ And there are lots of variations to 3-way 4-way once you get into SmartThings because you are only limited by programming now.
For example I do a 4-way setup in my master bedroom using a HD-100+ as the wall switch entering the room, controlling bedside smart bulbs on each side of the bed and a ceiling fan light. The HD-100+ isn’t even wired to a load per se because I wanted individual control of each light so instead I use its multitap “smarts” and indication readout. When I single tap UP;I turn on both bedside smart lamp bulbs, and the ceiling fan bulbs to 50% level and vice versa to shut down. Double & triple tapping controls the ceiling fan speeds and lights At each bedside I have wireless Minimotes that provide the “4-way” function. One button acts like the wall switch to toggle all lights, button 2 will only control the adjacent bedside lamp on-off or low dim; button 3 controls the opposite bedside lamp, button 4 the ceiling fan light. etc with press&hold functions of the minimote.
I just give you the example to let you know that thinking in a traditional 3-way and 4-way will limit you and the potential to take full advantage of Smartthings.