Yes and no. They are on different shards which splits the load. In theory nothing is different but in reality the newer shard has less users and typically gets updates a bit slower so it can be a bit more stable.
From a developer perspective have multiple shards has caused a few issues. But nothing show stopping.
We are getting pretty close to shard parity - at this point, the delay in updates getting rolled out across regions is usually less than a few hours. From the end-user perspective, the difference in updates pretty negligible.
Beware that I think any custom code (SmartApps or Device Type Handlers) that you write or paste into your “Account” is not automatically replicated between the Shards / Locations!