I have that exact Harmony remote. I works pretty well with Smatthings. You can assign any of the 4 orange buttons to any smarttings switch, and you don’t have to be in an activity to use them. That can be good and bad. Good because you don’t have to be in an activity to use them. Bad because you can change them per activity. The up/down rocker is not programmable. It only works it one of the other buttons is tied to a dimmer, then it controls the last dimmer that was activated.