Yes, need to power down or you can do it remotely from the IDE.
My Hub → List Utilities → Reboot hub
You can also do a Z-Wave repair from the same utilities page (wait for about a minute after the hub reboots before starting a repair)
Helps to have a repeater ideally, see this topic: FAQ: why would I need another beaming repeater if my zwave lock is already close to my hub?