Well, like in accounting, it depends. You have two ways:
There is something that is called a Do piston (change its mode in the main piston page). Then use the askAlexa CoRE Macro to run that piston. The Do pistons have no IFs.
The alternative is to create a simple piston using the Ask Alexa capability. You will have the chance to run something like IF (ask alexa macro) executed THEN (actions). Then you don’t have to use an Ask Alexa CoRE Macro, but any macro at all, even one that does nothing.
Choose wisely, red pill or blue pill… your choice…